ABSTRACT
Hepatitis B Virus (HBV) is an infection characterized as one of the major public health problems in the globe, particularly in Nigeria. This may be because of unguided sexual intercourse and inadequate knowledge of the disease. The study examined prevalence and incidence of HBV among expectant mothers in Lagos Island general hospital, Nigeria. Descriptive survey research design was used for the study. Hat and draw sampling technique was adopted for study location while volunteer sampling method was used to draw a hundred subjects. Instrument used was a revalidated questionnaire using test-retest method of reliability coefficient and the result yielded 0.89. The instrument was factor loaded using exploratory factor analysis setting nunnally criterion at 0.6. Hypotheses were tested using X2 statistics at 0.05 alpha level. Findings showed significant relationships in incidence of HBV based on unsafe sexual activity (X2= 62.8,p<0.05) and inadequate knowledge (X2=53.6,p<0.0). The practice of safe sex and being knowledgeable about HBV may prevent its incidence among expectant mothers. A significant relationship also exists in terms of managing the occurrence of HBV among expectant mothers (X2=47.6, p<0.05). This indicates that though there exist HBV, it can still be managed. The study concluded that inadequate knowledge, unsafe sexual activity may lead to HBV infection.
ABSTRACT
Studies on testes and epididymis tissue of rats treated orally for fourteen days with therapeutic doses of cloxacillin (6mg/100g/day), ampicillin (4mg/100/day) and tetracycline (12mg/100g/day) separately showed a significant reduction in testicular and epididimis architecture. Microscopic studies of these male reproductive organs further revealed a significant alteration in the epididymis as revealed by a significant reduction (p<0.05) in epididymal ductular diameter (EDD), and epididymal epithelial height (EEH) in treated group of animals. A significant increase (p<0.05) was however recorded in epididymal luminal diameter (ELD) in all the animals after the two and three week's recovery period allowed. This gives another insight into the toxicity activities of these antibiotics on male reproductive organs, apart from reduction in serum testosterone level, decreased sperm motility, decreased spermatozoa count and decrease in RNA and DNA content of spermatogenic cells as earlier reported.
Estudios referentes a testículos y tejido epididimario en ratas tratadas por vía oral durante catorce días, con dosis terapéuticas de cloxacilina (6mg/100g/día), ampicilina (4mg/100/día) y tetraciclina (12mg/100g/día) por separado muestran una reducción significativa en el peso testicular y epidídimario. Los estudios microscópicos de los órganos reproductores masculinos revelan además una alteración significativa en el epidídimo como se observa en la reducción del diámetro (p<0,05) de los conductos del epidídimo (EDD), y la altura del epitelio epididimal (EEH) en el grupo de los animales tratados. Sin embargo, se registró un aumento significativo (p <0,05) en el diámetro luminal del epidídimo (ELD) en todos los animales después de dos y tres semanas del período de recuperación. Esto genera otro punto de vista en relación a la toxicidad de estos antibióticos en los órganos reproductivos masculinos, además de la reducción de la concentración sérica de testosterona, disminución de la motilidad del esperma, disminución del recuento de espermatozoides y disminución en el contenido de ARN y ADN en las células de espermatogénesis como se reportó anteriormente.